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San Diego /sn dieo/ (Spanish for "Saint Didacus") is a major city in California, in San Diego County, on the coast of the Pacific Ocean in Southern California, approximately 120 miles (190 km) south of Los Angeles and immediately adjacent to the border with Mexico. With an estimated population of 1,394,928 as of July 1, 2015, San Diego is the eighth-largest city in the United States and second-largest in California. It is part of the San DiegoTijuana conurbation, the second-largest transborder agglomeration between the US and a bordering country after DetroitWindsor, with a population of 4,922,723 people. San Diego is known as "the birthplace of California" and is known for its mild year-round climate, natural deep-water harbor, extensive beaches, long association with the United States Navy and recent emergence as a healthcare and biotechnology development center. Historically home to the Kumeyaay people, San Diego was the first site visited by Europeans on what is now the West Coast of the United States. Upon landing in San Diego Bay in 1542, Juan Rodrguez Cabrillo claimed the entire area for Spain, forming the basis for the settlement of Alta California 200 years later. The Presidio and Mission San Diego de Alcal, founded in 1769, formed the first European settlement in what is now California. In 1821, San Diego became part of the newly-independent Mexico, which reformed as the First Mexican Republic two years later. In 1850, it became part of the United States following the MexicanAmerican War and the admission of California to the union. The city is the seat of San Diego County and is the economic center of the region as well as the San DiegoTijuana metropolitan area. San Diego's main economic engines are military and defense-related activities, tourism, international trade, and manufacturing. The presence of the University of California, San Diego (UCSD), with the affiliated UCSD Medical Center, has helped make the area a center of research in biotechnology.